Lehrstuhl für Biotechnologie und Biophysik

Collaborative Research Centre / Transregio 166
High-end light microscopy elucidates membrane receptor function

In the CRC/TRR 166 ReceptorLight high-end light microscopy techniques with highest spatial and time resolution are applied and further developed to gain deeper insight into the function of membrane receptors. The participating groups in Jena and Würzburg bundle their methodological expertise in the field of super-resolution microscopy, electrophysiology, and biophysics of membrane receptors to generate new insights into the function and distribution of diverse membrane receptors, and in parallel, to induce the development of new high-end light-microscopy methods.

 “ReceptorLight Symposium 1“, June 7-9. 2017, Tagungszentrum Juliusspital, Würzburg

This symposium will cover relevant topics from all fields of high-end light microscopy and its usability to study the function of membrane receptors.

For more informations see Symposium_ReceptorLight.pdf

and www.receptorlight.uni-jena.de

Quantification of membrane receptors: From single receptors to clinical applications

The Receptome harbors an uncharted number of therapeutic applications in health and disease. It comprises the entirety of receptor molecules in an organism and accounts for more than 5% of all proteins. The drug-receptor concept, which exploits the highly specific interaction between diffusible ligands and receptors, has led to the discovery and development of a large number of drugs that target specific receptors. However, despite their central therapeutic relevance, knowledge on specific receptor parameters, particularly for low abundant receptors remains elusive; this includes numbers, different functional states in response to different external stimuli, their distribution and interactions, as well as their operating modes.

In close collaboration with other departments and the university of Jena we aim to investigate receptors at all levels, from molecular mechanisms and functions, to cellular interactions and communication in both healthy and diseased model organisms. Together with the university hospital, we will translate our findings to clinical applications, therein improving current molecular diagnostics and personalized therapies.

The development of super-resolution microscopy has opened a window for the study of cellular processes at a nanomenter scale; it is now possible to investigate quantitatively how receptors are organized and how they interact at the molecular level. From such investigations, we are able to improve our knowledge of the relations between receptor localization, receptor abundance, and receptor functionality, which is key to understanding how alterations of malfunction of any of these parameters can lead to diverse diseases.


Center for Personalized Molecular Immunotherapy

The European Structural Funds supports two new projects of the University of Würzburg with more than EUR 4.3 million. In close cooperation with the University Hospital and regional companies, research activities aim to drive medical progress.

"The Bavarian State Ministry for Education, Science and the Arts funds two seminal projects which


Peptides as tags in fluorescence microscopy

Advance in biomedical imaging: The Biocenter of the University of Würzburg in close collaboration with the University of Copenhagen has developed an alternative approach to fluorescent tagging of proteins. The new probes are practicable and compatible with high-resolution microscopic procedures.

Fluorescence microscopy visualizes the molecula


Photometry unlocks 3D information from 2D localization microscopy data

We developed a straightforward photometric method, temporal, radial-aperture-based intensity estimation (TRABI), that allows users to extract 3D information from existing 2D localization microscopy data. TRABI uses the accurate determination of photon numbers in different regions of the emission pattern of single emitters to generate a z-dependent


Shedding light on an assistant protein

Observing in-protein motions with high spatial and temporal resolution: This is made possible by a new technology developed by scientists from the University of Würzburg, giving new insight into the functional mechanisms of very special proteins.

Proteins are among the functional key elements of life. Made up of long chains of amino acids, the

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