Lehrstuhl für Biotechnologie und Biophysik

Collaborative Research Center / Transregio 166
High-end light microscopy elucidates membrane receptor function

In the CRC/TRR 166 ReceptorLight high-end light microscopy techniques with highest spatial and time resolution are applied and further developed to gain deeper insight into the function of membrane receptors. The participating groups in Jena and Würzburg bundle their methodological expertise in the field of super-resolution microscopy, electrophysiology, and biophysics of membrane receptors to generate new insights into the function and distribution of diverse membrane receptors, and in parallel, to induce the development of new high-end light-microscopy methods.

 For more informations see www.receptorlight.uni-jena.de

 


Center for Personalized Molecular Immunotherapy

The European Structural Fund supports two new projects of the University of Würzburg with more than EUR 4.3 million. In close cooperation with the University Hospital and regional companies, research activities aim to drive medical progress.

"The Bavarian State Ministry for Education, Science and the Arts funds two seminal projects which the University of Würzburg runs jointly with regional companies by providing more than EUR 4.3 million in total from funds of the European Regional Development Fund", Bavarian Minister of State, Dr Ludwig Spaenle, announced a few days ago.   more >>

Super-resolution microscopy can unravel previously hidden details of cellular structures but requires high irradiation intensities to use the limited photon budget efficiently. Such high photon densities are likely to induce cellular damage in live-cell experiments.  more >>

News

Peptides as tags in fluorescence microscopy

Advance in biomedical imaging: The Biocenter of the University of Würzburg in close collaboration with the University of Copenhagen has developed an alternative approach to fluorescent tagging of proteins. The new probes are practicable and compatible with high-resolution microscopic procedures.

Fluorescence microscopy visualizes the molecula

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Photometry unlocks 3D information from 2D localization microscopy data

We developed a straightforward photometric method, temporal, radial-aperture-based intensity estimation (TRABI), that allows users to extract 3D information from existing 2D localization microscopy data. TRABI uses the accurate determination of photon numbers in different regions of the emission pattern of single emitters to generate a z-dependent

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Shedding light on an assistant protein

Observing in-protein motions with high spatial and temporal resolution: This is made possible by a new technology developed by scientists from the University of Würzburg, giving new insight into the functional mechanisms of very special proteins.

Proteins are among the functional key elements of life. Made up of long chains of amino acids, the

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Microscopy: Nine at one blow

Advance in biomedical imaging: The University of Würzburg's Biocenter has enhanced fluorescence microscopy to label and visualise up to nine different cell structures simultaneously.

Fluorescence microscopy allows researchers to visualise biomolecules in cells. They label the molecules using fluorescent probes, excite them with light and use t

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